Corticospinal excitability accompanying ballistic wrist movements in primary dystonia
Identifieur interne : 003D58 ( Main/Exploration ); précédent : 003D57; suivant : 003D59Corticospinal excitability accompanying ballistic wrist movements in primary dystonia
Auteurs : Colum D. Mackinnon [États-Unis] ; Miodrag Velickovic [États-Unis] ; Cristina Drafta [États-Unis] ; Alexander Hesquijarosa [États-Unis] ; Mitchell F. Brin [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-03.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Botulinum Toxins, Type A (therapeutic use), Dystonia, Dystonic Disorders (diagnosis), Dystonic Disorders (drug therapy), Dystonic Disorders (physiopathology), EMG patterns, Electromyography (instrumentation), Excitability, Female, Humans, Magnetics, Male, Middle Aged, Muscle, Skeletal (physiopathology), Nervous system diseases, Neuromuscular Agents (therapeutic use), Pyramidal Tracts (physiopathology), Reaction Time, Wrist, Wrist (physiopathology), bradykinesia, corticospinal excitability, dystonia, transcranial magnetic stimulation.
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- diagnosis : Dystonic Disorders.
- drug therapy : Dystonic Disorders.
- instrumentation : Electromyography.
- physiopathology : Dystonic Disorders, Muscle, Skeletal, Pyramidal Tracts, Wrist.
- Adult, Female, Humans, Magnetics, Male, Middle Aged, Reaction Time.
Abstract
Current models of basal ganglia dysfunction in primary dystonia propose that the excessive muscle activity results from an increase in the excitability of the primary motor cortex. Neurophysiological and neuroimaging studies, however, have shown consistently reduced movement‐related sensorimotor cortical activity. To explore this paradox, we used transcranial magnetic stimulation (TMS) to examine changes in corticospinal excitability preceding and during ballistic movements of the wrist in 9 patients with primary dystonia affecting the arm and 9 matched control subjects. The onset time, rate of rise, and duration of changes in the excitability of corticospinal projections to the agonist muscle were normal in the patients with dystonia. Increases in excitability were selective to the initial agonist muscle, suggesting that the spatial recruitment of corticospinal neurons was normal. Nonetheless, movements were slower in the patients by an average of 26%. The onset of the first agonist muscle burst was normal in magnitude and timing but the activity in this muscle subsequently became attenuated as movement progressed. Muscle activity in antagonist and proximal muscles of the upper arm was reduced significantly in the dystonia patients. These findings support the view that movement preparation and initiation at the level of the primary motor cortex is normal in patients with dystonia. Bradykinesia could not be attributed to co‐contraction or overflow of activity and was associated with reduced rather than excessive muscle activity. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20017
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-03">2004-03</date><biblScope unit="vol">19</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="273">273</biblScope><biblScope unit="page" to="284">284</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">911504CEE59DC626E4B9BB37352D01CCA06EAB54</idno><idno type="DOI">10.1002/mds.20017</idno><idno type="ArticleID">MDS20017</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Botulinum Toxins, Type A (therapeutic use)</term><term>Dystonia</term><term>Dystonic Disorders (diagnosis)</term><term>Dystonic Disorders (drug therapy)</term><term>Dystonic Disorders (physiopathology)</term><term>EMG patterns</term><term>Electromyography (instrumentation)</term><term>Excitability</term><term>Female</term><term>Humans</term><term>Magnetics</term><term>Male</term><term>Middle Aged</term><term>Muscle, Skeletal (physiopathology)</term><term>Nervous system diseases</term><term>Neuromuscular Agents (therapeutic use)</term><term>Pyramidal Tracts (physiopathology)</term><term>Reaction Time</term><term>Wrist</term><term>Wrist (physiopathology)</term><term>bradykinesia</term><term>corticospinal excitability</term><term>dystonia</term><term>transcranial magnetic stimulation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term><term>Neuromuscular Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonic Disorders</term><term>Muscle, Skeletal</term><term>Pyramidal Tracts</term><term>Wrist</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Magnetics</term><term>Male</term><term>Middle Aged</term><term>Reaction Time</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term><term>Excitabilité</term><term>Poignet</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Current models of basal ganglia dysfunction in primary dystonia propose that the excessive muscle activity results from an increase in the excitability of the primary motor cortex. Neurophysiological and neuroimaging studies, however, have shown consistently reduced movement‐related sensorimotor cortical activity. To explore this paradox, we used transcranial magnetic stimulation (TMS) to examine changes in corticospinal excitability preceding and during ballistic movements of the wrist in 9 patients with primary dystonia affecting the arm and 9 matched control subjects. The onset time, rate of rise, and duration of changes in the excitability of corticospinal projections to the agonist muscle were normal in the patients with dystonia. Increases in excitability were selective to the initial agonist muscle, suggesting that the spatial recruitment of corticospinal neurons was normal. Nonetheless, movements were slower in the patients by an average of 26%. The onset of the first agonist muscle burst was normal in magnitude and timing but the activity in this muscle subsequently became attenuated as movement progressed. Muscle activity in antagonist and proximal muscles of the upper arm was reduced significantly in the dystonia patients. These findings support the view that movement preparation and initiation at the level of the primary motor cortex is normal in patients with dystonia. Bradykinesia could not be attributed to co‐contraction or overflow of activity and was associated with reduced rather than excessive muscle activity. © 2004 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Mackinnon, Colum D" sort="Mackinnon, Colum D" uniqKey="Mackinnon C" first="Colum D." last="Mackinnon">Colum D. Mackinnon</name></region><name sortKey="Brin, Mitchell F" sort="Brin, Mitchell F" uniqKey="Brin M" first="Mitchell F." last="Brin">Mitchell F. Brin</name><name sortKey="Drafta, Cristina" sort="Drafta, Cristina" uniqKey="Drafta C" first="Cristina" last="Drafta">Cristina Drafta</name><name sortKey="Hesquijarosa, Alexander" sort="Hesquijarosa, Alexander" uniqKey="Hesquijarosa A" first="Alexander" last="Hesquijarosa">Alexander Hesquijarosa</name><name sortKey="Velickovic, Miodrag" sort="Velickovic, Miodrag" uniqKey="Velickovic M" first="Miodrag" last="Velickovic">Miodrag Velickovic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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